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Submitted
March 13, 2025
Accepted
May 10, 2025
Published
June 30, 2025
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Abstract

Interleukin-17A (IL-17A) plays a pivotal role in the pathogenesis of psoriatic arthritis. We generated a high-affinity monoclonal antibody against IL-17A using hybridoma technology and characterized its binding kinetics, neutralization potency, and in vivo efficacy in an experimental arthritis model. The antibody demonstrated superior affinity compared to existing therapeutics and significantly reduced disease severity in treated animals. These results support the potential of this novel antibody as a therapeutic candidate. 

Keywords

Cytokine Inhibition IL-17A Inflammation Monoclonal Antibody Psoriatic Arthritis Therapeutic Antibodies

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Copyright (c) 2025 Widad Abd Aljabbar Mozzan, Nada Khazal K. Hindi, Ashwaq M. S. Al-Jbouri, Yasmeen Ali Hussein, Hayder Al-Aubaidy (Author)

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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1.
Mozzan WAAJ, Hindi NKK, Al-jburi A, Ali Hussein Y, Al-Aubaidy H. Generation and Characterization of a Novel Anti-IL-17A Monoclonal Antibody for the Treatment of Psoriatic Arthritis. TPB [Internet]. 2025 Jun. 30 [cited 2025 Nov. 8];3(1):49-63. Available from: https://mail.tpb.nabea.pub/tpb/article/view/27
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How to Cite

1.
Mozzan WAAJ, Hindi NKK, Al-jburi A, Ali Hussein Y, Al-Aubaidy H. Generation and Characterization of a Novel Anti-IL-17A Monoclonal Antibody for the Treatment of Psoriatic Arthritis. TPB [Internet]. 2025 Jun. 30 [cited 2025 Nov. 8];3(1):49-63. Available from: https://mail.tpb.nabea.pub/tpb/article/view/27

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